The comedic trailer for The Layover has been released. The film pins Kate Upton and Alexandra Daddario as two recently unemployed best friends ready to shake things up in their lives. When the duo decide to take a trip to Florida, things get messy when their flight is rerouted to St. Louis and a passenger on their flight comes between them. Upton and Daddario go through ridiculous measures to win the affection of the guy, and ruin their friendship in the process. William H. Macy (Shameless) directed the film, which also stars Kal Penn, Molly Shannon, Matt Barr, and Macy himself. Check out the trailer above.